منابع مشابه
The Role of Leukotrienes in Respiratory Tract and Asthma
Polyunsaturated fatty acids play a role as precursors of biologically active compounds that can act as mediators or modulators of various cell functions. Thus three main groups of derivatives the prostaglandins, the thromboxanes, and recently discovered leukotrienes are formed by oxygenation and further transformation of various polyunsaturated fatty acids of which arachidonic acid plays t...
متن کاملLeukotrienes in the pathogenesis of asthma.
Asthma is a chronic inflammatory disease that is associated with widespread but variable airflow obstruction. The mechanisms that lead to airflow obstruction in asthma are bronchoconstriction, mucosal edema, increased secretion of mucus, and an inflammatory-cell infiltrate that is rich in eosinophils. Leukotrienes (LTs) B4, C4, D4, and E4 have been shown experimentally to play a role in each of...
متن کاملExhaled breath condensate cysteinyl leukotrienes and airway remodeling in childhood asthma: a pilot study
BACKGROUND It has been suggested that cysteinyl leukotrienes (cysLTs) play an important role in airway remodeling. Previous reports have indicated that cysLTs augment human airway smooth muscle cell proliferation. Recently, cysLTs have been measured in exhaled breath condensate (EBC). The aim of this study was to evaluate the relationship between cysLTs in EBC and another marker of airway remod...
متن کاملIL-23 Gene and Protein Expression in Childhood Asthma
Background: Asthma is the chronic inflammation of airways characterized by eosinophilic infiltration, mucus overproduction, airway hyper-responsiveness and airway remodeling. These changes are induced mostly by cytokines which are produced by T helper (Th) 2 cells. Recently, the role of interleukin-23 (IL-23) in the pathogenesis of adultallergic asthma has been studied. Objective: To explore IL...
متن کاملAddition to inhaled corticosteroids of long-acting beta2-agonists versus anti-leukotrienes for chronic asthma.
BACKGROUND Asthma patients who continue to experience symptoms despite taking regular inhaled corticosteroids (ICS) represent a management challenge. Long-acting beta2-agonists (LABA) and anti-leukotrienes (LTRA) are two treatment options that could be considered as add-on therapy to ICS. OBJECTIVES To compare the safety and efficacy of adding LABA versus LTRA to the treatment regimen for chi...
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ژورنال
عنوان ژورنال: Medical Journal Armed Forces India
سال: 2002
ISSN: 0377-1237
DOI: 10.1016/s0377-1237(02)80139-3